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Literature summary extracted from

  • Larsen, K.S.; Ostergaard, H.; Olsen, O.H.; Bjelke, J.R.; Ruf, W.; Petersen, L.C.
    Engineering of substrate selectivity for tissue factor-factor VIIa complex signaling through protease-activated receptor 2 (2010), J. Biol. Chem., 285, 19959-19966.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.21 D72N the mutant shows 13% of wild type FVIIa signaling activity towards protease-activated receptor 2 Homo sapiens
3.4.21.21 Q143N the mutant reduces interleukin-8 expression to background levels but maintains essentially normal pro-coagulant activity Homo sapiens
3.4.21.21 Q217E the mutant shows enhanced protease-activated receptor 2 activation Homo sapiens
3.4.21.21 Q40A the mutant reduces interleukin-8 expression to background levels but maintains essentially normal pro-coagulant activity Homo sapiens
3.4.21.21 T151A the mutant shows 13% of wild type FVIIa signaling activity towards protease-activated receptor 2 Homo sapiens
3.4.21.21 T151S the variant activates macromolecular coagulation substrates and supports signaling of the ternary tissue factor-FVIIa-Xa complex normally but is severely impaired in binary tissue factor-FVIIa-protease-activated receptor 2 signaling Homo sapiens
3.4.21.21 T99A the mutant shows 17% of wild type FVIIa signaling activity towards protease-activated receptor 2 Homo sapiens
3.4.21.21 T99Y the mutation leads to enhanced protease-activated receptor 2 activation (2-3fold above the wild type FVIIa activity) Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.21 factor IX + H2O Homo sapiens FVIIa catalyzes activation of factor X factor IXa + ?
-
 ?
3.4.21.21 Factor X + H2O Homo sapiens FVIIa catalyzes activation of factor X Factor Xa + ?
-
 ?
3.4.21.21 protease-activated receptor 2 + H2O Homo sapiens protease-activated receptor 2 is cleaved by FVIIa in the binary tissue factor-FVIIa complex ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.21 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.21 factor IX + H2O FVIIa catalyzes activation of factor X Homo sapiens factor IXa + ?
-
 ?
3.4.21.21 Factor X + H2O FVIIa catalyzes activation of factor X Homo sapiens Factor Xa + ?
-
 ?
3.4.21.21 protease-activated receptor 2 + H2O protease-activated receptor 2 is cleaved by FVIIa in the binary tissue factor-FVIIa complex Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.21 factor VIIa
-
 Homo sapiens
3.4.21.21 FVIIa
-
 Homo sapiens